Luis A. Bagatolli





Luis A. Bagatolli obtained his M. Sc. (1991) and Ph. D. degree (1995) from the School of Chemical Sciences, University of Córdoba in Argentina. After a postdoctoral research at Laboratory for Fluorescence Dynamic, University of Illinois at Urbana- Champaign, USA (1997-2000), and a brief stay in Argentina, he joined in 2002 MEMPHYS- Center for Biomembrane Physics at the University of Southern Denmark (SDU) where he worked until February 2017. At present, he is a Researcher (Investigador Principal) of the Argentinian Research Council (CONICET) in a node located in the city of Córdoba (Instituto de Investigación Medica Mercedes y Martín Ferreyra). He is also an associated member at MEMPHYS- international and interdisciplinary research network.

Research Interest

My current research interests are related to physicochemical (biophysical) aspects of biological systems, particularly the effect of non-equilibrium conditions, crowding and spatial confinement in membranous systems and cells. I am also interested in the development and applications of biophotonic-related techniques to biological systems (fluorescence spectroscopy, imaging techniques based in multiphoton excitation microscopy). I have authored numerous papers, review articles and book chapters, including 2 books, on topics such as lipid-lipid and lipid-proteins interactions in membranes (composed of synthetic lipid mixtures, natural membrane’s lipid extracts, naturally occurring biological membranes) and performed studies on skin tissue.

Relevant Publications

  • Vida ¿una cuestíon de grasas? Una perspectiva desde la biofísica de membranas. Luis A. Bagatolli y Ole G. Mouritsen. Yachay EP, Ecuador. Edicion electrónica revisada (2017) (download)
  • Vida ¿una cuestíon de grasas? Una perspectiva desde la biofísica de membranas. Luis A. Bagatolli y Ole G. Mouritsen. Yachay EP, Ecuador (2014). ISNB 978-9942-07-694-6
  • Life -as a matter of fat: Lipids in a membrane biophysics perspective. Ole G. Mouritsen and Luis A. Bagatolli. Springer (2016). ISBN 978-3-319-22613-2 view►
Crowding and Cells
  • Bagatolli, L.A. and Stock, R. P. 2016. "The cell as a gel: material for a conceptual discussion" Physiological Mini Reviews 9(5): 38-49 view►.
  • Bagatolli, L.A. and Stock, R. P. 2016. "The use of 6-acyl-2-(dimethylamino)naphtalenes as relaxation probes of biological environments" In Perspectives on Fluorescence: A Tribute to Gregorio Weber. D.M Jameson Ed., Springer Series on Fluorescence, pp. 197-216  view►
  • Malacrida L. , Astrada, S., Briva,A.,  Bolatti-Fogolín, M., Gratton, E. and L. A. Bagatolli. 2016. "Spectral Phasor analysis of LAURDAN fluorescence in live A549 lung cells to study the hydration and time evolution of intracellular lamellar bodies-like structures." Biochim. Biophys. Acta - Biomembranes, 1858(11):2625-2635 view►
  • Seir Thoke H., Tobiasen A., Brewer J., Lyngs Hansen P., Stock R. P., Folke Olsen L. and Bagatolli L.A. 2015. "Tight coupling of metabolic oscillations and intracellular water dynamics in Saccharomyces cerevisiae" PLoS ONE 10(2): e0117308. doi:10.1371/journal.pone.0117308. view►
  • J. Brewer, H.S. Thoke, R.P. Stock and L.A. Bagatolli. 2017. "Enzymatic studies on planar supported membranes using a widefield fluorescence LAURDAN Generalized Polarization imaging approach", Biochim. Biophys. Acta - Biomembranes, 1859: 888-895 view►
  • Mouritsen O.G. and Bagatolli L.A. 2015. "Lipid domains in model membranes: a brief historical perspective" Essays in Biochemistry 57:1-19.view►
  • L.A. Bagatolli and D. Needham. 2014. "Quantitative optical microscopy and micromanipulation studies on the lipid bilayer membranes of giant unilamellar vesicles", review article, Chem. Phys. Lipids 181:99-120. view►
  • Bagatolli L.A. and Mouritsen O.G. 2013. "Is the fluid mosaic (and the accompanying raft hypothesis) a suitable model to describe fundamental features of biological membranes? What may be missing?" Front. Plant Sci. 4:457. view►
  • Bagatolli L.A., Ipsen J.H., Simonsen A.C., Mouritsen O.G., 2010, “An outlook on organization of lipids in membranes: searching for a realistic connection with the organization of biological membranes” Prog. Lip. Research 49(4):378-89. view►
  • Bagatolli L.A. 2006 “To see or not to see: lateral organization of biological membranes and fluorescence microscopy” Biochim Biophys Acta 1758:1541-1556. view►
  • Parasassi T. E., Krasnowska K., Bagatolli L.A. and Gratton E. 1998. "Laurdan and Prodan as polarity sensitive fluorescence membrane probes" J. of Fluorescence 8:365-373. view►
Skin tissue
  • Bloksgaard M., Brewer J., Pashkovski E.,  Ananthapadmanabhan K. P.,  Ahm Sørensen J. and  Bagatolli L.A. 2014."Effect of detergents on the physico-chemical properties of skin stratum corneum: A two-photon excitation fluorescence microscopy study" Int J. Cosmetic Science 36(1):39-45. view►
  • Bloksgaard M., Brewer J., Bagatolli L.A. 2013. "Structural and dynamical aspects of skin studied by multiphoton excitation fluorescence microscopy-based methods" Eur J Pharm Sci. 50(5):586-94. view►
  • BrewerJ., Kubiak J., Bloksgaard M., Sørensen J. A. and Bagatolli L.A. 2013. “Spatially resolved two color diffusion measurements in human skin applied to transdermal liposome penetration” J. Investig. Dermatol. 133:1260–1268 view►
  • Iwai I., Han H.M., Svensson S.,  Öfverstedt L.-G.,Anwar J., Brewer J., Bloksgaard M., den Holländer L., Laloeuf A., Nosek D., Masich S., Bagatolli L.A., Skoglund U. and Norlen L.. 2012. "The human skin barrier is organized as stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety" J. Investig. Dermatol. 132(9):2215-25. view►.
  • Carrer D.C., Vermehren C., Bagatolli L.A. 2008. "Pig skin structure and transdermal delivery of liposomes: a two photon microscopy study" J. Controlled Release 132(1):12-20. view►


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